AIwithCare
Category: AI in Healthcare
An AI-powered clinical trial screening platform that uses generative AI and retrieval-augmented generation (RAG) to automatically match patients to clinical trials by analyzing electronic health records for eligibility. AIwithCare was founded in 2025. The company is led by Alexander 'A.J.' Blood, MD, MSc. Based in Boston, United States. Team size: N/A (Newly spun out startup). Total funding raised: Not publicly disclosed. Latest round: Spinout/Institutional funding (December 2025). Key investors include ["Mass General Brigham Innovation"].
- Founded
- 2025
- Headquarters
- Boston, United States
- Team size
- N/A (Newly spun out startup)
- Total funding
- Not publicly disclosed
Value proposition
Accelerates clinical trial recruitment by automating patient screening and eligibility determination, reducing enrollment timelines and improving patient access to trials.
Products and solutions
["RECTIFIER Platform (RAG-Enabled Clinical Trial Infrastructure for Inclusion Exclusion Review)","AI-powered clinical trial screening and patient matching engine","Electronic health record analysis system for trial eligibility","Multi-specialty clinical trial screening across cardiology, gastroenterology, neurology, oncology, pathology, and psychiatry"]
Unique value
Leverages Mass General Brigham's extensive patient dataset and clinical expertise to develop specialized AI models for precise patient-trial matching, validated through peer-reviewed research showing superior performance to manual screening methods.
Target customer
Healthcare systems, pharmaceutical companies, clinical research organizations (CROs), and academic medical centers running clinical trials
Industries served
["Clinical Research","Pharmaceuticals","Healthcare Systems","Biotechnology","Medical Research"]
Technology advantage
Proprietary Retrieval-Augmented Generation (RAG) technology specifically designed for clinical trial screening, reported to achieve high accuracy metrics (e.g., 94.7% and 98%) and to double enrollment rates compared to manual screening in randomized trials.
How they differentiate
RAG-enabled RECTIFIER platform with strong clinical validation from Mass General Brigham, demonstrated 2x enrollment rates in randomized trials, and integration with health system EHR workflows across multiple specialties.
Main competitors
["Deep 6 AI","Mendel.ai","Tempus"]
Key partnerships
["Mass General Brigham (parent organization and primary deployment site)","Academic research collaborations through Mass General Brigham's Accelerator for Clinical Transformation","Pharmaceutical industry relationships via research collaborations and grants","Healthcare technology infrastructure providers"]
Notable customers
["Mass General Brigham"]
Major milestones
["December 2025: Official spinout from Mass General Brigham as AIwithCare","Published research in NEJM AI showing strong performance versus manual screening","Randomized controlled trial demonstrating 2x enrollment rates compared to manual screening in heart failure clinical trials","RECTIFIER platform deployed across multiple specialties at Mass General Brigham including cardiology, gastroenterology, neurology, oncology, pathology, and psychiatry"]
Growth metrics
Deployed across 20+ clinical and research applications at Mass General Brigham; reported 94.7% accuracy in pediatric gastroenterology referral triage; 98% accuracy in identifying critical labs and symptoms from clinical notes; randomized trial demonstrating 2x enrollment rates versus manual screening.
Market positioning
Clinical trial AI screening platform with academic health system validation, targeting healthcare providers and research organizations.
Geographic focus
United States (initially), with potential for global expansion through institutional partnerships
Patents and IP
No registered patents publicly disclosed as of December 2025
About Alexander 'A.J.' Blood, MD, MSc
Cardiologist and Intensivist at Brigham and Women's Hospital; Associate Director of Accelerator for Clinical Transformation at Mass General Brigham; Instructor of Medicine at Harvard Medical School; board-certified in internal medicine and cardiovascular disease
Official website: https://aiwithcare.com